منابع مشابه
The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.
Reciprocal chromosomal translocations are recurrent features of many hematological malignancies. The cloning of the genes located at the breakpoints of chromosomal translocations in leukemia and lymphoma has led to the identification of new genes involved in carcinogenesis. Molecular studies of the breakpoint of several translocations involving chromosomal band 11q23 led to the cloning of a gen...
متن کامل11q23/MLL acute leukemia : update of clinical aspects.
Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous treatment with DNA topoisomerase II inhibitors. 11q23/MLL abnormalities have been widely recognized as an important prognostic factor in AL. Over 70 chromosome partners of 11q23 have been identified to date, at least 50...
متن کاملChromosomal fragile sites and cancer-specific rearrangements.
I T IS NOW WELL established that human tumors, particularly leukemias and lymphomas, are characterized by nonrandom chromosomal abnormalities. During the past 2 years, a number of proto-oncogenes and transforming genes have been mapped to the chromosomal breakpoints involved in the specific structural rearrangements. Experimental evidence obtained recently suggests that the genes located at the...
متن کاملChromosomal insertion sites for phages and plasmids.
Bacteriophages insert their DNA into host chromosomes either through transposition (as in phage Mu) or through site-specific recombination (as in phage X). Whereas Mu can insert almost anywhere along the chromosome, X has a single highly preferred chromosomal site. Certain plasmids also insert into chromosomes by site-specific recombination. The site-specific recombinases used generally belong ...
متن کاملChromosomal binding sites of Ultrabithorax homeotic proteins
Drosophila homeotic genes and their vertebrate cognates, the Hox genes, encode homeodomain proteins that are thought to control segment-specific morphogenesis by regulating subordinate target genes. Although expression of many genes is thought to be influenced by homeotic/Hox function, little is known about the genes they directly regulate in the developing embryo. One of the Drosophila homeoti...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1998
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401017